Table 2.
Efficacy.
| Target vessel diameter in DSA | PtiO2 (mmHg) | TCD (cm/sec) | CTP (no. of ROIs with MTT < 6.5) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient No. | Baseline (mm) | After titration (% from baseline) | 24 h (% from baseline) | 48 h (% from baseline) | Baseline | After titration | 4 h | 12 h | 24 h | 48 h | Baseline | After titration | 4 h | 12 h | 24 h | 48 h | Baseline | Scan 1 | Scan 2 |
| 1 | 2.40 | 2.4 (0) | 2.01 (−16.3) | 2.1 (−12.5) |
27.0 | 6.2 | 34.2 | 28.9 | 24.9 | 32.6 | 239 | 199 | 109 | 96 | 180 | 103 | 31 | 15 | |
| 2 | 1.6 | 1.8 (12.5) | 0.9 (−43.8) | 1 (−37.5) |
8.0 | 10.1 | 15.7 | 21.4 | 22.1 | 89 | 147 | 120 | 135 | 139 | 32 | 8a | |||
| 3 | 0.96 | 1.64 (70.8) | 2.14 (122.9) | 30.7 | 46.4 | 47.6 | 38.5 | 45.7 | 91 | 57 | 94 | 81 | 90 | 31 | 15b | ||||
| 4 | 1 | 0.9 (−10.0) |
0.8 (−20.0) | 20.7 | 27.3 | … | 27.4 | 26.4 | NA | NA | NA | NA | NA | … | … | ||||
| 5 | 0.88 | 0.95 (8.0) | 0.9 (2.3) | 0,73 (−17.0) |
39.3 | 45.5 | 52.5 | 33.0 | 27.9 | 17.9 | 74 | 68 | 60 | 130 | 97 | 130 | 11 | 30 | 24 |
| 6 | 1.51 | 1.49 (−1.3) |
1,5 (−0.7) | 28.4 | 31.8 | 31.7 | 37.3 | 52.4 | 41 | 24 | 35 | 22 | 38 | 3 | 0 | ||||
| 7 | 0.67 | 0.92 (25.0) | 1.61 (140.3) | 19.8 | 24.6 | 26.6 | 30.4 | 38.3 | 140 | 113 | 66 | 46 | 59 | 17 | 13 | ||||
DSA, digital subtraction angiography; PtiO2, brain tissue oxygen; TCD, transcranial Doppler; CTP, computed tomography perfusion; ROI, region of interest; MTT, mean transit time;
a
CTP was performed one day after iNO cessation;
b
CTP was performed 2 days after iNO cessation. Green color indicates that the respective endpoint was reached.