Table 4.

Vaginal laser therapy in breast cancer survivors: Summary of studies and their outcomes.

Ref.	Yr	n 1	Design	Treatment	Conclusion
Pieralli et al[223]	2016	50	Prospective Before-after study	3 sessions of Fractional Microablative CO2 Laser every 30 d	The treatment seems to be feasible and effective
Pagano et al[221]	2016	26	Observational retrospective study	3 sessions of Fractional Microablative CO2 Laser every 30 d	The treatment seems to be effective and with good tolerance
Gambacciani et al[218]	2017	43	Pilot before-after study	3 sessions of Vaginal Erbium Laser every 30 d	The treatment seems to be effective
Pagano et al[214]	2018	82	Observational retrospective study	3 sessions of Fractional Microablative CO2 Laser every 30 d	The treatment seems to be effective
Mothes et al[225]	2018	16	Retrospective study	1 session of Vaginal Erbium YAG Laser	The treatment seems to be effective
Pearson et al[222]	2019	26	Single-arm pilot study Before-After study	3 sessions of Fractional Microablative CO2 Laser every 30 d	The treatment seems to improve sexual function and vaginal atrophy
Areas et al[224]	2019	24	Open, prospective study	3 sessions of Vaginal Erbium YAG Laser every 30 d	The treatment seems to improve sexual function and vaginal atrophy

¹Cases.