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. Author manuscript; available in PMC: 2022 Jun 2.
Published in final edited form as: ACS Chem Neurosci. 2021 May 14;12(11):1972–1982. doi: 10.1021/acschemneuro.1c00072

Figure 1.

Figure 1.

Fractional species1 from pulsed HDX-MS for different regions of Aβ peptic peptides and their kinetic fits for each peptide showing a plateau in HDX, respectively. Time-dependent fractional species1 from peptic peptides following HDX-MS for the Arctic (E22G) mutant (A) and kinetic fits for normalized fractional species1 (protected species) that showed a plateau phase by HDX-MS (B). HDX-MS data showing fractional species1 of peptides obtained from the Iowa (D23N) mutant (C) and kinetic fits of those peptides for normalized fractional species1 that showed a plateau by HDX-MS (D). Fractional species1 of various HDX-MS peptides from the Italian (E22K) (E) mutant with corresponding kinetic fits for normalized fractional species1 (F) that exhibited a plateau in HDX-MS. The peptic peptides are color coded: 1-9 (2+) black open circle, 1-19 (2+) blue open circle, 20-34 (2+) green closed circle, 21-34 (2+) dark green closed circle, and 35-42 (1+) orange closed circle.