. Author manuscript; available in PMC: 2022 Jun 2.

Published in final edited form as: ACS Chem Neurosci. 2021 May 14;12(11):1972–1982. doi: 10.1021/acschemneuro.1c00072

Table 2.

Rates of the primary process, λ, and the secondary process, κ, as well as the critical seed concentration above which secondary processes become the main source of new aggregates. In the fast aggregating mutants, the lag phase is so short that an assumption about lambda had to be made, based on previously measured rates (starred entries in the table), to obtain sufficient constraints.

name	mutation	lambda (λ) (s⁻¹)	kappa (κ) (s⁻¹)	crit. seed conc. (M)
Arctic	E22G	7.47E-04*	1.01E-02	1.36E-07
Iowa	D23N	3.59E-04*	6.52E-03	7.56E-08
Italian	E22K	4.10E-04*	2.09E-03	9.63E-07
Dutch	E22Q	4.35E-09	7.19E-04	9.17E-16
English	H6R	1.29E-05	4.07E-05	2.50E-06
wild type	-	1.06E-05	1.98E-04	7.10E-08
Japanese	D7N	4.57E-05	1.89E-05	1.46E-04
Flemish	A21G	2.19E-06	9.84E-05	1.24E-08