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. 2022 Feb 18;9:822429. doi: 10.3389/fnut.2022.822429

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Copyright © 2022 Xiang, Chi, Han, Shi, Cai, Xiang and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of strains on liver, small intestine, IM and SCFAs in AH mice, and correlation between IM and host parameters. (A) ALT and AST in serum. (B) Hepatic mRNA expression of Mcp-1, Tnf-α, and Il-1β. (C) Serum LPS level. (D) Immunocytochemistry for occludin in the ileum (magnification: 400 ×). (E) SCFA content in the small intestine. (F) Bacterial composition at the genus level in Proteobacteria, and relative abundance of SCFA producers in the small intestine. (G) Spearman correlation of small intestinal and cecal microbiota and host parameters (p < 0.05). Results (A–E) were shown as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 compared with CON group, and #p < 0.05, ##p < 0.01, ###p < 0.001 compared with AH group by ANOVA one-way statistical analysis.