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. 2022 Mar 3;8:93. doi: 10.1038/s41420-022-00897-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Key biological pathways with potentially higher activity in rd1 (a) and lower activity in rd1 treated with CN03 (b). Pathways are ranked according to their p-values and colored by their q-values. A q value is the p-value adjusted for multiple testing using the Benjamini-Hochberg procedure [79, 80]. The node size indicates the gene ratio, i.e., the percentage of total genes or proteins in the given KEGG pathways (only input genes or proteins with at least one KEGG pathway were included in the calculation). c The overlap between kinases changed in rd1 NT vs. WT and vs. rd1 treated with CN03 respectively (Figs. 2c, 3c), is visualized in a Venn Diagram. Here, increased or reduced activity of a kinase is indicated by arrows pointing up- or down-wards, respectively.