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. 2022 Mar 3;12:3500. doi: 10.1038/s41598-022-07394-y

Figure 6.

Figure 6

Long-term SD tumor cells are more sensitive to molecular inhibitors when the target has been activated by irradiation. PC3 cells were irradiated with a single dose (SD) of 10 Gy and cultured for 2 months. Unirradiated cells were used as control. Colony formation assays were used to determine sensitivity to molecular targeted drugs. At 24 h after plating, cells were incubated with inhibitors at indicated concentrations or DMSO (0.1%) for 24 h. Results show mean ± STDEV (n = 3, *P < 0.05, **P < 0.01, Student’s t-test).