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. 2022 Mar 3;12:3500. doi: 10.1038/s41598-022-07394-y

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Long term SD tumor cells are more resistant to HDAC inhibition. Gene expression of (A) histones and (B) HDACs in PC3 cells at 24 h (short-term) or at 2 months (long-term) after a single-dose (SD) irradiation of 10 Gy or after a multifractionated (MF) irradiation of 10 times 1 Gy. Unirradiated cells have been used as control. (C) HDAC protein expression determined by reverse phase protein microarray and (D) clonogenic survival in long-term 10 Gy SD cells. Results show mean ± STDEV (n = 3, *P < 0.05, **P < 0.01, Student’s t-test).