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. 2022 Mar 3;12:3531. doi: 10.1038/s41598-022-06377-3

Table 2.

Factors of lung cancers by using Cox regression model.

Variables Crude HR 95% CI 95% CI P Adjusted HR 95% CI 95% CI P
AChEI (reference: without) 1.240 0.792 1.798 0.198 1.198 0.765 1.774 0.167
Age ≥ 65 (reference: age of 50–64) 1.524 1.165 1.823 < 0.001 1.498 1.124 1.798 < 0.001
Pneumonia (reference: without) 2.501 2.134 2.801 < 0.001 2.495 2.101 2.786 < 0.001
Bronchiectasis (reference: without) 1.776 1.254 2.148 < 0.001 1.754 1.241 2.131 < 0.001
Pneumoconiosis (reference: without) 2.345 1.955 2.794 < 0.001 2.284 1.925 2.765 < 0.001
PAP (reference: without) 1.731 1.213 2.124 < 0.001 1.724 1.201 2.111 < 0.001
Hypertension (reference: without) 1.848 1.364 2.124 < 0.001 1.842 1.345 2.097 < 0.001
Stroke (reference: without) 1.767 1.303 2.048 < 0.001 1.752 1.289 2.035 < 0.001
Coronary artery disease (reference: without) 1.772 1.296 2.010 < 0.001 1.722 1.264 1.999 < 0.001
Diabetes mellitus (reference: without) 1.598 1.134 1.995 < 0.001 1.579 1.124 1.986 < 0.001
Chronic kidney disease (reference: without) 2.341 1.598 2.685 < 0.001 2.297 1.583 2.674 < 0.001
Depression (reference: without) 1.682 1.168 1.989 < 0.001 1.591 1.154 1.984 < 0.001
Anxiety (reference: without) 1.703 1.203 2.024 < 0.001 1.687 1.197 2.015 < 0.001
Smoking-related diseases (reference: without) 1.099 1.037 1.134 0.017 1.095 1.033 1.129 0.014
Dementia (reference: without) 1.089 1.026 1.129 0.024 1.087 1.024 1.124 0.026
CCI_R 1.127 1.103 1.149 < 0.001 1.124 1.101 1.145 < 0.001
Medical center (reference: local hospital) 1.602 1.131 2.005 < 0.001 1.598 1.128 1.986 < 0.001
Regional hospital (reference: local hospital) 1.467 1.108 1.996 < 0.001 1.451 1.105 1.973 < 0.001

HR hazard ratio, CI confidence interval, Adjusted HR Adjusted variables listed in the table 1, AChEI acetylcholinesterase inhibitors, CCI_R Charlson Comorbidity Index, dementia removed, PAP pulmonary alveolar pneumonopathy.