Table 2.
Genes associated with chemoresistance in both human B-ALL cell lines.
| Genes associated with chemoresistance, signaling, and adhesion in both human B-ALL cell lines. REH & RCH-AcV (ACM + MTX); p-value cutoff of 0.05 |
|---|
| Upregulated |
| LGALS9 |
| ST3GAL6 |
| LGALSL |
| LGALS1 |
| LGALS3BP |
| LGALS8 |
| CD44 |
| CD69 |
| ICAM1 |
| ICAM2 |
| ICAM3 |
| ICAM4 |
| ICAM5 |
| PCDH1 |
| PCDHGC3 |
| PCDH9 |
| CDH24 |
| CDH2 |
| ITGA4 |
| ITGB1BP1 |
This table contains genes identified as being associated with chemoresistance in both cell lines using a p-value cutoff of 0.05. The p-value cutoff of 0.05 was used to nominate upregulated genes associated with adhesion and aggregation which could be involved in the induction of chemoresistance. We chose to focus on Galectin-9 in this study because the LGALS9 gene validated in several human B-ALL cell lines and its surface expression was the only one consistently upregulated on human B-ALL cells (n = 8) cultured in adipocyte-conditioned medium.