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. 2022 Mar 3;7:16. doi: 10.1038/s41525-022-00289-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Differential abundance analysis adjusted for age and sex identified differentially underexpressed and overexpressed metabolite ratio tests in media from samples of PHTS individuals with ASD/DD relative to PHTS individuals with cancer. Correlation plot showing prominent negative correlation blocks (red rectangles). Circles shown are for results significant at P < 0.05, with increasing diameter/color corresponding with increasing correlation (circles omitted otherwise). b Using the media compartment, unsupervised hierarchical clustering shows that significant differentially abundant metabotypes distinctly separate PHTS individuals with cancer from those who have ASD/DD, with the exception of two patients. ASD autism spectrum disorder, DD developmental delay.