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. 2022 Feb 8;54(2):115–128. doi: 10.1038/s12276-022-00727-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a p16, p21, and p53 mRNA levels increased in the motor cortex (cx) and hippocampus (HP) in α-syn tg mice compared with those of wild-type mice. b Immunohistochemistry of WT and α-syn tg (3 months) mice with the anti-phospho-α-synuclein antibody. Note that phosphorylated α-synuclein increased in the parietal cortex, hippocampal CA1 region, and DG of α-synuclein tg mice. Phosphorylated α-synuclein increased more in the older tg (8.5 months) mice than in the 3-month tg mice. c Immunohistochemistry of WT and α-syn TG (3 months) mice with the anti-γH2AX antibody. Note that γH2AX increased in the parietal cortex, hippocampal CA1 region, and DG of α-synuclein tg mice. γH2AX increased more in the older tg (8.5 months) mice than in the 3-month tg mice.