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. 2022 Mar 3;12:3526. doi: 10.1038/s41598-022-07591-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PS-OCT imaging of the left eye of a 43-year-old woman from the potential sunset group (Case 6 in Supplementary Table S1). (a) Color fundus images showed faint diffuse depigmentation. The black line in the color fundus image designates the scan line for PS-OCT B-scan images. (b) Standard OCT B-scan image. (c) Binary DOPU B-scan image (DOPU < 0.8) showing preservation of RPE melanin (red arrow) and mild reduction of choroidal melanin (white arrow). (d) Choroidal thickness map. (e) ChMeT map and (f) ChMeTratio map showing decreased choroidal melanin compared with healthy control eyes (Fig. 1) and non-sunset eyes (Fig. 2).