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. 2022 Mar 3;12:3549. doi: 10.1038/s41598-022-07597-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of Genscript sVNT with the Wantai SARS-CoV-2 NAbs ELISA (A) and the Euroimmun NeutraLISA (B). Data points are color-coded according to their positivity in PRNT (blue: PRNT negative, orange: PRNT positive). Gray dashed line in (A): Wantai nABs ELISA manufacturer-recommended cutoff. Shaded areas in (A,B): equivocal areas; in-house for GenScript sVNT and manufacturer-recommended for Euroimmun NeutraLISA. (A) As the Wantai Nabs ELISA is marketed for qualitative use, the manufacturer does not recommend a conversion of the raw data into binding inhibition and hence no correlation to the sVNT was calculated. Due to the competitive nature of the assay, the signal is inversely correlated with the amount of neutralizing antibodies in a sample. Identical sample sets were used in (A,B) (N = 111).