Table 1.

Genetic correlations between smoking status and T2D, CVDs, and related metabolic traits (α = 0.05/15).

Phenotype 1	Phenotype 2		Rg	Rg_SE	p-Value
Smoking status	T2D		0.170	0.018	9.39E−22*
	CVDs	CAD	0.234	0.022	1.96E−27*
		MI	0.226	0.026	1.08E−17*
		HF	0.276	0.030	8.43E−20*
		IS	0.164	0.057	3.70E−03
		ICH	0.188	0.080	1.80E−02
		AF	0.029	0.029	3.17E−01
	Glycemic traits	FG	0.105	0.042	1.31E−02
		FI	0.048	0.055	3.84E−01
		HOMA−β	−0.012	0.052	8.13E−01
		HOMA−IR	0.064	0.058	2.72E−01
	Blood lipids	LDL−C	0.022	0.030	4.77E−01
		HDL−C	−0.094	0.024	6.14E−05
		TC	0.032	0.026	2.11E−01
		TG	0.096	0.026	2.00E−04

Rg, genetic correlation estimate; SE, standard error of genetic correlation estimate; T2D, type 2 diabetes; CAD, coronary artery disease; MI, myocardial infarction; HF, heart failure; IS, ischemic stroke; ICH, intracerebral hemorrhage; AF, atrial fibrillation; FG, fasting glucose; FI, fasting insulin; HOMA-β, β-cell function obtained by homeostasis model assessment; HOMA-IR, insulin resistance obtained by homeostasis model assessment; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.

*A significant p-value after Bonferroni correction.