Figure 4.

SDC enhanced the antitumor efficacy of Sorafenib in nude mice. (A) Tumor size. Representative pictures of tumors from each group. The picture was taken on the 32nd day after implantation. Mice were treated with saline; Sorafenib alone at 20 mg/kg; SDC alone at 50 mg/kg; Sorafenib 20 mg/kg plus SDC 50 mg/kg (SDC was given 1 hour before Sorafenib administration). (B) Changes in tumor volume in 32 days. Each point represents the mean ± SD of tumor volumes from 4 mice in each group. (C) SDC attenuated hepatotoxicity induced by Sorafenib. Serum levels of AST, ALT, and the ratio of AST/ALT in SDC group, Sorafenib group, and the combination, #P < .05, compared with the control group, *P < .05, compared with sorafenib group.