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. 2022 Feb 18;16:843025. doi: 10.3389/fncir.2022.843025

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Copyright © 2022 Qi and Feldmeyer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acetylcholine-induced Vm changes are related to the L4 RS, FS and nFS neuron (sub)types. (A) Box plots of ACh-induced Vm changes in L4 RS, FS and nFS neurons. Individual data points are given on the right. P value was calculated using the non-parametric Wilcoxon–Mann–Whitney two-sample rank test. *** p < 0.001. Dashed lines indicate the Vm change at ±0.5 mV. (B) Histograms of ACh-induced V_m changes for two L4 RS neuron subtypes: spiny stellate cells and star pyramidal neurons. No statistically significant difference was found between two subtypes. (C) Histograms of ACh-induced V_m changes for three L4 FS neuron subtypes: small basket cells, basket cells, and translaminar cells. No statistically significant difference was found among three subtypes. (D) Histograms of ACh-induced V_m changes for five L4 nFS neuron subtypes: local projecting (putative SST+, non-Martinotti cell-like), supragranular projecting (putative SST+, Martinotti cell-like), NGF, VIP+-like and unclassified interneurons. VIP+-like interneurons show the strongest depolarisation of the five subtypes. Statistically significant differences (*) were found between VIP+-like and three other interneuron subtypes (LP, SP, NG).