Table 3.
Comparison of various biomarkers of different cognitive levels in the sWMH group.
| Variable | NC (n = 26) | mVCI (n = 52) | sVCI (n = 64) | F/H | P | Tukey/Bonferron adjusted | ||
|---|---|---|---|---|---|---|---|---|
| NC vs. mVCI | NC vs. sVCI | mVCI vs. sVCI | ||||||
| Erythrocyte (× 1012/L)a | 4.56 ± 0.51 | 4.21 ± 0.50 | 4.12 ± 0.60 | 6.094 | 0.003** | 0.026* | 0.002** | 0.606 |
| Hb (g/L)a | 137.00 ± 16.70 | 128.19 ± 16.30 | 128.20 ± 18.34 | 4.401 | 0.014* | 0.105 | 0.010* | 0.539 |
| Platelets (× 109/L)b | 208.00 (67.50) | 220.00 (79.50) | 223.00 (86.25) | 2.742 | 0.254 | / | / | / |
| Lymphocytes(×109/L)b | 1.97 (0.72) | 1.54 (0.72) | 1.55 (0.63) | 5.718 | 0.057 | / | / | / |
| hs-CRP (mg/L)b | 1.22 (2.41) | 2.20 (4.01) | 4.68 (10.52) | 12.803 | 0.002** | 0.895 | 0.004** | 0.024* |
| Hcy (μmol/L)b | 15.68 (6.43) | 14.49 (5.35) | 15.64 (7.27) | 1.840 | 0.398 | / | / | / |
| RBP (mg/L)b | 40.00 (9.58) | 38.40 (16.30) | 33.35 (14.20) | 6.201 | 0.045* | 1.000 | 0.117 | 0.123 |
| Cr (μmol/L)b | 76.10 (24.75) | 67.00 (31.50) | 68.00 (23.00) | 2.853 | 0.240 | / | / | / |
| UN (mmol/L) b | 5.17 (1.32) | 5.12 (1.87) | 5.37 (2.39) | 1.195 | 0.550 | / | / | / |
| β2-M (mg/L)b | 2.12 (0.94) | 2.50 (0.95) | 2.40 (0.91) | 3.401 | 0.183 | / | / | / |
| ALP (U/L)b | 65.00 (25.50) | 70.00 (23.75) | 73.00 (23.00) | 2.002 | 0.368 | / | / | / |
| TG (mmol/L)b | 1.45 (1.13) | 1.29 (0.75) | 1.25 (0.82) | 0.034 | 0.983 | / | / | / |
| HDL-C (mmol/L)b | 1.08 (0.36) | 0.95 (0.39) | 0.99 (0.43) | 1.383 | 0.501 | / | / | / |
| LDL-C (mmol/L)b | 2.40 (1.40) | 2.07 (1.09) | 2.40 (1.15) | 3.296 | 0.192 | / | / | / |
| VLDL-C (mmol/L)b | 0.37 (0.28) | 0.33 (0.20) | 0.36 (0.26) | 0.902 | 0.637 | / | / | / |
| IMA (U/mL)a | 77.36 ± 4.01 | 77.18 ± 4.23 | 78.43 ± 4.06 | 1.479 | 0.232 | / | / | / |
| PA (mg/L)a | 259.44 ± 50.11 | 258.62 ± 67.28 | 227.05 ± 68.15 | 4.229 | 0.016* | 0.998 | 0.085 | 0.027* |
*P < 0.05,**P < 0.01. aShown as mean ± standard deviation. bShown as median (IQR). Abbreviations: ALP, alkaline phosphatase; β2-M, β2 microglobulin; Cr, creatinine; Hb, hemoglobin; Hcy, homocysteine; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; IMA, ischemia modified albumin; LDL-C, low-density lipoprotein cholesterol; mVCI, mild vascular cognitive impairment; NC, normal cognition; PA, prealbumin; RBP, retinol binding protein; sWMH, severe white matter hyperintensities; sVCI, severe vascular cognitive impairment; TG, triglycerides; UN, urea nitrogen; VLDL-C, very low-density lipoprotein cholesterol.