FIG. 5.

Schematic representation of the role of vesicles within the RV replication complex as precise sites of viral RNA synthesis. The vesicles of the replication complex are postulated to provide a protective environment for the synthesis of nascent viral genomic RNA. Newly synthesized viral RNA is then rapidly encapsidated by RV capsid proteins, which are synthesized from the adjacent RER. The mechanisms involved in the translocation of the resulting nucleocapsids for interaction with RV E2-E1 heterodimers have not been defined.