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. 2022 Feb 18;13:826266. doi: 10.3389/fneur.2022.826266

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Copyright © 2022 Cosgrove, Saadon, Mikell, Stefancin, Alkadaa, Wang, Saluja, Servider, Razzaq, Huang and Mofakham.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) An example of PFC regions of interest with colors representing each one. Yellow = dlPFC; green = OFC; teal = ACC; red = mPFC. (B) Thalamo-prefrontal tractography from two representative patients: one with damage to thalamo-prefrontal projections and one without. An area of decreased thalamo-prefrontal projections in the patient with damage to these connections is represented by a circle. This same area in the patient with intact projections is circled as well. dlPFC, dorsolateral prefrontal cortex; ACC, anterior cingulate cortex; mPFC, medial prefrontal cortex; OFC, orbitofrontal cortex.