Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 17;9(7):2102182. doi: 10.1002/advs.202102182

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

A schematic diagram of the mechanism of LAP induction in macrophages after IRFA: the macrophages in residual tumors engulf dying tumor cells, activate NOX2, and produce ROS for LAP formation. Cholesterol efflux during LAP enhances IL‐4‐mediated macrophage programming and activates the PI3Kγ/AKT pathway. Cytokines including CCL7 and IL‐10 are produced following LAP. Simultaneously, inhibition of LAP and blockade of the PI3Kγ/AKT pathway remodels the immunosuppressive state of macrophages. The schematic diagram is created with BioRender.com.