Figure 6.

Body fluid manipulation techniques. a) Iontophoretic delivery of a chelating agent for breaking apart the tight junctions through sequestration of calcium, increasing the flux of analytes in conjunction with reverse iontophoresis. Reproduced with permission.^{[ 205 ]} Copyright 2018, PLoS. b) Hollow needles with substantially greater extraction of ISF due to the inherent flow restrictions with any polymer‐based methodology. Reproduced with permission.^{[ 20 ]} Copyright 2018, Springer Nature.