TABLE 2.

Associations of dietary intakes and plasma proportions of PUFAs at 8 and 16 y with prevalence and incidence of asthma at 24 y analyzed by logistic regression¹

	Prevalent asthma 24 y	Incident asthma 8–24 y
Dietary PUFAs (mg/1900 kcal), ≥median vs. <median (n = 1992)2
n–3 PUFAs
ALA
8 y (≥1145.0)	1.03 (0.80, 1.32)	0.89 (0.65, 1.24)
16 y (≥1330.7)	0.95 (0.74, 1.23)	1.03 (0.75, 1.42)
∑VLC n–3
8 y (≥234.5)	1.01 (0.78, 1.30)	0.83 (0.60, 1.15)
16 y (≥268.8)	0.97 (0.75, 1.25)	0.94 (0.68, 1.30)
n–6 PUFAs
LA
8 y (≥6249.1)	1.41 (1.10, 1.82)	1.32 (0.96, 1.83)
16 y (≥7850.3)	0.92 (0.71, 1.18)	0.94 (0.68, 1.30)
AA
8 y (≥70.7)	0.94 (0.73, 1.21)	0.95 (0.69, 1.31)
16 y (≥77.0)	1.32 (1.02, 1.70)	1.19 (0.86, 1.64)
n–6:n–3 ratio
8 y (≥4.6)	1.15 (0.89, 1.48)	1.46 (1.05, 2.03)
16 y (≥4.8)	0.96 (0.75, 1.24)	0.98 (0.71, 1.36)
Plasma PUFAs (% of total) , ≥median vs. <median (n = 831)3
n–3 PUFAs
ALA
8 y (≥0.24)	0.63 (0.43, 0.91)	0.63 (0.39, 1.04)
16 y (≥0.28)	0.82 (0.56, 1.18)	0.71 (0.44, 1.16)
∑VLC n–3
8 y (≥3.3)	0.55 (0.38, 0.81)	0.59 (0.36, 0.97)
16 y (≥5.4)	0.74 (0.51, 1.08)	0.59 (0.36, 0.98)
n–6 PUFAs
LA
8 y (≥21.2)	0.76 (0.52, 1.10)	0.76 (0.47, 1.23)
16 y (≥21.9)	0.68 (0.47, 0.99)	0.84 (0.52, 1.36)
AA
8 y (≥5.6)	0.65 (0.44, 0.94)	0.69 (0.42, 1.13)
16 y (≥8.9)	1.04 (0.72, 1.52)	1.07 (0.66, 1.75)

¹Values are OR (95% CI). ORs were estimated by logistic regression models adjusted for sex, allergic heredity, parental occupation at baseline, and maternal smoking in pregnancy and/or infancy. AA, arachidonic acid (20:4n–6); ALA, α-linolenic acid (18:3n–3); DPA, docosapentaenoic acid (22:5n–3); LA, linoleic acid (18:2n–6); n–6:n–3 ratio, sum of LA and AA divided by sum of ALA, EPA (20:5n–3), DPA, and DHA (22:6n–3); ∑VLC n–3, sum of very-long-chain n–3 PUFAs (EPA, DPA, and DHA).

²Prevalent asthma 24 y, n = 291 of 1992; incident asthma 8–24 y, n = 169 of 1770.

³Prevalent asthma 24 y, n = 142 of 831; incident asthma 8–24 y, n = 76 of 715.