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. 2022 Feb 18;16:747215. doi: 10.3389/fnhum.2022.747215

FIGURE 6.

FIGURE 6

A 29-year-old right-handed woman with sudden onset of fluent aphasia. (Top row) MRI acquired in acute setting; (A) Axial DWI shows a left frontal and thalamic acute ischemia (due to patent foramen ovale); (B) tb-fMRI [verb generation task; p < 0.05; without restriction of cluster size (k = 0)] shows BOLD activation in the contralateral homotopic area (white arrow). The absence of significant activations in the left hemisphere could be caused by changes in the local blood flow secondary to ischemia. Functional activation at the level of the skull shell is related to mild motion artifact. Bottom row: MRI acquired four months after the event; (C) axial FLAIR shows post-ischemic changes in the left frontal and thalamic areas; (D) tb-fMRI [verb generation task; p < 0.05; without restriction of cluster size (k = 0)] shows BOLD activation in the left frontal area (white arrow head), as well as in the contralateral right frontal area (white arrow).