TABLE 4.
In vitro effects of antibacterial agents on phagocyte functions
| Function | Drugs that increase function | Drugs that decrease function | Drugs with no effect on function |
|---|---|---|---|
| Chemotaxis | Nafcillin, clindamycin, erythromycin, bacitracin, chloramphenicol, dapsone, lincomycin | Tetracycline, clindamycin, erythromycin, gentamicin, fusidic acid, clofazimine | Tetracycline, clindamycin, erythromycin, gentamicin, chloramphenicol, quinolones, rifampin, β-lactams |
| Phagocytosis | Erythromycin, chloramphenicol, nafcillin | Tetracycline, tobramycin, polymyxin B | Tetracycline, gentamicin, polymyxin B, rifampin |
| Oxidative burst | Clindamycina, cefotaxime, quinolones, cefpimizole, josamycin | Cyclines, cefotaximeb, trimethoprim, rifampin, fusidic acidc, sulfonamides, chloramphenicol, erythromycin A (and derivatives) | Cyclines, clindamycin, quinolones, rifampin, fusidic acid, sulfonamides, chloramphenicol, spiramycin, glycopeptides, aminoglycosides |
| Bacterial killingd | Cefotaxime, cefodizime, roxithromycin | Sulfonamides, aminoglycosides | Rifampin, polymyxin |
| Cytokinese | Cefotaxime (IL-1), cefaclor (IL-1), cefodizimef (IL-1, IFN), erythromycin A derivatives (IL-10), ofloxacin (IL-2), spiramycin (IL-6) | Cefoxitin, cefodizime (IL-1, -8, TNF), erythromycin A derivatives (IL-1, IL-6, IL-8, TNF), ofloxacin, ciprofloxacin (IL-1, TNF) |
a
Depends on concentrations.
b
In monocytes.
c
In PMN.
d
Depends on bacterial species.
e
Depends on cytokines.
f
Restoration in immunocompromised animals.