TABLE 5.

Effects of antibacterial agents on the specific immune system and complement activation

Function	Drugs that increase function	Drugs that decrease function
In vitro
Complement inactivation		Sulfonamides, tetracycline, ampicillin, streptomycin, gentamicin
T and B lymphocytes	Cefotaxime, cefodizime, erythromycin A, fosfomycin, dapsone, ciprofloxacin	Cefmenoxime, josamycin, fusidic acid, cyclines, chloramphenicol, rifampin, clofazimine, co-trimoxazole, ampicillin
In vivo, ex vivo
T and B responses	Cefotaxime, cefodizime, dapsone, erythromycin A	Cyclines, ampicillin, mezlocillin, clofaximine
Graft survival	Chloramphenicol, fusidic acid, doxycycline, rifampin	Trimethoprim, rifampin
Tumor growth	Mezlocillin, doxycycline, rifampin	Trimethoprim, rifampin
Antibody protection	Cefotaxime, cefodizime	Chloramphenicol, co-trimoxazole, rifampin, josamycin, doxycycline
Delayed-type hypersensitivity	Cefodizime	Mezlocillin, cyclines, metronidazole, rifampin, erythromycin A

^aRestoration in immunocompromised animals. 

^bDepends on the administration schedule.