Table 1. Baseline Patient and Tumor Characteristics (n = 288).
Characteristic | No. (%) | P valuea | ||
---|---|---|---|---|
Whole group (n = 288) | Nonengrafters (n = 90) | Engrafters (n = 198) | ||
Sex | ||||
Female | 112 (39) | 32 (36) | 80 (40) | .50 |
Male | 176 (61) | 58 (64) | 118 (60) | |
Age at diagnosis, y | ||||
Mean (SD) | 63.3 (12.3) | 63.8 (10.9) | 63.1 (12.9) | .90 |
Median (range) | 63.5 (22-94) | 64.0 (33-90) | 63.0 (22-94) | |
Smoking history | ||||
No | 96 (33) | 25 (28) | 71 (36) | .40 |
Yes | 182 (63) | 62 (68) | 120 (61) | |
Not reported | 10 (3) | 3 (3) | 7 (4) | |
Subsite | ||||
Tongue | 152 (53) | 42 (47) | 110 (56) | .20 |
Floor of mouth | 53 (19) | 24 (27) | 29 (15) | |
Buccal mucosa | 29 (10) | 12 (13) | 17 (9) | |
Upper/lower gingiva | 27 (9) | 6 (7) | 21 (11) | |
Retromolar trigone | 14 (5) | 5 (5) | 9 (4) | |
Other | 12 (4) | 1 (1) | 11 (5) | |
pT category | ||||
T1-2 | 176 (61) | 56 (62) | 120 (61) | .90 |
T3-4 | 112 (39) | 34 (38) | 78 (39) | |
pN category | ||||
N0-1 | 170 (59) | 59 (66) | 111 (56) | .20 |
N2-3 | 118 (41) | 31 (34) | 87 (44) | |
Overall stage, 7th edition | ||||
I | 33 (12) | 13 (14) | 20 (10) | .50 |
II | 58 (20) | 21 (23) | 37 (19) | |
III | 52 (18) | 14 (16) | 38 (19) | |
IVA-B | 145 (50) | 42 (47) | 103 (52) | |
Histological grade | ||||
1-2 | 203 (70) | 67 (74) | 136 (69) | .40 |
3 | 85 (30) | 23 (26) | 62 (31) | |
Max primary tumor size, cm | ||||
Mean (SD) | 3.3 (1.4) | 3.1 (1.4) | 3.4 (1.4) | .10 |
Median (range) | 3.0 (0.3-8.6) | 3.0 (1-8.6) | 3.2 (0.3-8.5) | |
Tumor thickness, mm | ||||
Mean (SD) | 13.7 (8.8) | 13.0 (8.9) | 14.0 (8.8) | .21 |
Median (range) | 11 (1-45) | 10 (2-45) | 12 (1-45) | |
Extranodal extension | ||||
No | 214 (74) | 80 (89) | 134 (68) | .001 |
Yes | 74 (26) | 10 (11) | 64 (32) | |
Total LN positive | ||||
Mean (SD) | 2.1 (3.3) | 1.3 (1.8) | 2.4 (3.7) | .004 |
Median (range) | 1 (0-31) | 0 (0-8) | 1 (0-31) | |
Level IV/V LN involvement | ||||
No | 246 (85) | 82 (91) | 164 (83) | .10 |
Yes | 42 (15) | 8 (9) | 34 (17) | |
PORT | ||||
No | 117 (41) | 45 (50) | 72 (36) | .04 |
Yes | 171 (59) | 45 (50) | 126 (64) | |
Concurrent chemotherapy | ||||
No | 239 (83) | 82 (91) | 157 (79) | .03 |
Yes | 49 (17) | 8 (9) | 41 (21) | |
Early recurrence | ||||
No | 262 (91) | 89 (99) | 173 (87) | .003 |
Yes | 26 (9) | 1 (1) | 25 (13) | |
Overall recurrence | ||||
No | 167 (58) | 66 (73) | 101 (52) | .001 |
Yes | 121 (42) | 24 (27) | 97 (48) |
Abbreviations: LN, lymph node; PORT, postoperative radiation therapy.
P value represents statistical comparison between engrafters and nonengrafters.