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. 2022 Mar 3;148(4):342–349. doi: 10.1001/jamaoto.2022.0003

Table 1. Baseline Patient and Tumor Characteristics (n = 288).

Characteristic No. (%) P valuea
Whole group (n = 288) Nonengrafters (n = 90) Engrafters (n = 198)
Sex
Female 112 (39) 32 (36) 80 (40) .50
Male 176 (61) 58 (64) 118 (60)
Age at diagnosis, y
Mean (SD) 63.3 (12.3) 63.8 (10.9) 63.1 (12.9) .90
Median (range) 63.5 (22-94) 64.0 (33-90) 63.0 (22-94)
Smoking history
No 96 (33) 25 (28) 71 (36) .40
Yes 182 (63) 62 (68) 120 (61)
Not reported 10 (3) 3 (3) 7 (4)
Subsite
Tongue 152 (53) 42 (47) 110 (56) .20
Floor of mouth 53 (19) 24 (27) 29 (15)
Buccal mucosa 29 (10) 12 (13) 17 (9)
Upper/lower gingiva 27 (9) 6 (7) 21 (11)
Retromolar trigone 14 (5) 5 (5) 9 (4)
Other 12 (4) 1 (1) 11 (5)
pT category
T1-2 176 (61) 56 (62) 120 (61) .90
T3-4 112 (39) 34 (38) 78 (39)
pN category
N0-1 170 (59) 59 (66) 111 (56) .20
N2-3 118 (41) 31 (34) 87 (44)
Overall stage, 7th edition
I 33 (12) 13 (14) 20 (10) .50
II 58 (20) 21 (23) 37 (19)
III 52 (18) 14 (16) 38 (19)
IVA-B 145 (50) 42 (47) 103 (52)
Histological grade
1-2 203 (70) 67 (74) 136 (69) .40
3 85 (30) 23 (26) 62 (31)
Max primary tumor size, cm
Mean (SD) 3.3 (1.4) 3.1 (1.4) 3.4 (1.4) .10
Median (range) 3.0 (0.3-8.6) 3.0 (1-8.6) 3.2 (0.3-8.5)
Tumor thickness, mm
Mean (SD) 13.7 (8.8) 13.0 (8.9) 14.0 (8.8) .21
Median (range) 11 (1-45) 10 (2-45) 12 (1-45)
Extranodal extension
No 214 (74) 80 (89) 134 (68) .001
Yes 74 (26) 10 (11) 64 (32)
Total LN positive
Mean (SD) 2.1 (3.3) 1.3 (1.8) 2.4 (3.7) .004
Median (range) 1 (0-31) 0 (0-8) 1 (0-31)
Level IV/V LN involvement
No 246 (85) 82 (91) 164 (83) .10
Yes 42 (15) 8 (9) 34 (17)
PORT
No 117 (41) 45 (50) 72 (36) .04
Yes 171 (59) 45 (50) 126 (64)
Concurrent chemotherapy
No 239 (83) 82 (91) 157 (79) .03
Yes 49 (17) 8 (9) 41 (21)
Early recurrence
No 262 (91) 89 (99) 173 (87) .003
Yes 26 (9) 1 (1) 25 (13)
Overall recurrence
No 167 (58) 66 (73) 101 (52) .001
Yes 121 (42) 24 (27) 97 (48)

Abbreviations: LN, lymph node; PORT, postoperative radiation therapy.

a

P value represents statistical comparison between engrafters and nonengrafters.