Table 4.
Summary of Toxicitiesa in Patients Treated With HU for ≥ 3 Months
| Adverse Event | n (%) (n = 1381) |
|---|---|
| Nonhematologic | 100 (7.2) |
| Gastrointestinal disorders | 89 (6.4) |
| Aphthous stomatitis | 2 (0.1) |
| Colitis ulcerative | 1 (0.1) |
| Constipation | 24 (1.7) |
| Diarrhea | 30 (2.2) |
| Duodenal ulcer | 1 (0.1) |
| Intestinal perforation | 1 (0.1) |
| Nausea | 29 (2.1) |
| Stomatitis | 9 (0.7) |
| Vomiting | 13 (0.9) |
| Skin and subcutaneous tissue disorders | 14 (1.0) |
| Decubitus ulcer | 1 (0.1) |
| Skin ulcer | 13 (0.9) |
Abbreviation: HU = hydroxyurea.
a
These are treatment-emergent adverse events and were not necessarily attributed to HU.