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. 2022 Feb 18;12:826655. doi: 10.3389/fonc.2022.826655

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Copyright © 2022 VanderVere-Carozza, Gavande, Jalal, Pollok, Ekinci, Heyza, Patrick, Masters, Turchi and Pawelczak

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of replication protein A inhibitor (RPAi) 329 combination treatment. (A) Chou-Talalay analysis of combination with chemotherapeutics. The combination index (CI) is plotted as a function of the fraction of cell affected (Fa) for each treatment combination of the 329. (B) Chou-Talalay analysis of combination with DDR-targeted agents as described in panel (A).