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Vehicle/excipient screen.
| Vehicle | Solubility (mg/m I) |
|---|---|
| Water | <1 |
| 50 mM sodium acetate pH 4 | <1 |
| 30% SBECD in water | <1 |
| Oleic acid | 2.4 |
| Cremophor EL | <1 |
| Labrasol | 1.1 |
| Propylene glycol | 1.3 |
| Polyethylene glycol 400 | 1.2 |
| NMP | 70.4 |
| Polysorbate 8O | <1 |
| Ethanol | <1 |
A series of additives, excipients, and co-solvents were assessed in basic formulation studies to optimize bioavailability.
