Table 2.
Association between Detected Protein Levels (Detergent-Insoluble Fraction) and Last Clinical Diagnosis in All Participants (N = 40)
| Protein | Last clinical diagnosis, n (%) |
P value∗ | |
|---|---|---|---|
| Normal + MCI | Dementia | ||
| ApoE | |||
| Undetected† | 15 (93.8) | 9 (37.5) | 6.71 × 10−4 |
| Detected | 1 (6.2) | 15 (62.5) | |
| APP | |||
| Undetected† | 10 (62.5) | 5 (20.8) | 0.018 |
| Detected | 6 (37.5) | 19 (79.2) | |
| MAPT | |||
| Undetected† | 3 (18.8) | 2 (8.3) | 0.37 |
| Detected | 13 (81.2) | 22 (91.7) | |
| SNCA | |||
| Undetected† | 16 (100) | 13 (54.2) | 0.0012 |
| Detected | 0 (0) | 11 (45.8) | |
ApoE, Apolipoprotein E; MCI, mild cognitive impairment.
∗
P value was calculated by Fisher’s exact test (undetected versus detected and normal + MCI versus dementia).
†
MASCOT score <30.