Table 3.
Association between Detected Protein Levels (Detergent-Insoluble Fraction) and Last Clinical Diagnosis in Participants without the APOE ε4 Allele (n = 26)
| Protein | Last clinical diagnosis, n (%) |
P value∗ | |
|---|---|---|---|
| Normal + MCI | Demented | ||
| ApoE | |||
| Undetected† | 13 (92.9) | 5 (41.7) | 0.0093 |
| Detected | 1 (7.1) | 7 (58.3) | |
| APP | |||
| Undetected† | 8 (57.1) | 5 (41.7) | 0.69 |
| Detected | 6 (42.9) | 7 (58.3) | |
| MAPT | |||
| Undetected† | 2 (14.3) | 2 (16.7) | 1 |
| Detected | 12 (85.7) | 10 (83.3) | |
| SNCA | |||
| Undetected† | 14 (100) | 6 (50) | 0.0040 |
| Detected | 0 (0) | 6 (50) | |
ApoE, Apolipoprotein E; MCI, mild cognitive impairment.
∗
P value was calculated by Fisher's exact test [undetected versus detected and normal + MCI versus dementia].
†
MASCOT score <30.