Table 7.
Immunohistochemical Staining for ApoE in Amygdala Sections from a Convenience Sample of 14 Cases from the University of Kentucky AD Research Center Biobank
| Case # | Age, years | Sex | Final MMSE score | Braak NFT stage | CERAD neuritic amyloid plaque severity | APOE allele status | ApoE MS result | ApoE stained astrocytes∗ | ApoE IHC-stained AD-type pathology† |
|---|---|---|---|---|---|---|---|---|---|
| 1068 | 92 | F | 22.5 | VI | Moderate | 2/3 | 51.1 | + | + |
| 1298 | 96 | F | 24 | VI | Severe | 2/3 | 36.4 | ++ | ++ |
| 5384 | 87 | M | 0 | V | Moderate | 3/3 | 151.9 | ++ | + |
| 1096 | 84 | M | 23 | VI | Severe | 3/3 | 151.4 | ++ | ++ |
| 1309 | 83 | F | 30 | II | None | 3/3 | 0 | +++ | – |
| 1106 | 79 | M | 29 | II | Severe | 3/3 | 44.1 | + | ++ |
| 1053 | 90 | F | 22.5 | VI | Severe | 3/3 | 85.9 | ++ | ++ |
| 5372 | 94 | M | 24 | V | Severe | 3/3 | 113.1 | ++ | ++ |
| 5394 | 64 | F | 6 | VI | Severe | 3/4 | 248.5 | + | +++ |
| 1101 | 86 | F | 7 | VI | Severe | 3/4 | 374.5 | + | ++ |
| 1052 | 80 | F | 19 | VI | Moderate | 3/4 | 348.9 | + | +++ |
| 1035 | 84 | F | 19 | V | Severe | 3/4 | 46.2 | + | +++ |
| 1037 | 82 | M | 17.5 | VI | Severe | 3/4 | 253.7 | + | +++ |
| 5361 | 87 | M | 13 | V | Severe | 4/4 | 59 | + | +++ |
F, female; M, male; AD, Alzheimer disease; ApoE, Apolipoprotein E; IHC, immunohistochemistry; MCI, mild cognitive impairment; MMSE, Mini–Mental State Examination; MS, mass spectrometry; NFT, neurofibrillary tangle.
ApoE IHC staining of cells resembling reactive astrocytes in amygdala: minimal (+), moderate (++), and widespread (+++).
AD neuropathologic change features stained with ApoE IHC in amygdala: none (–); a minimal number of focal senile plaque-like structures (+), moderate densities of senile-plaque–like structures (++), or widespread senile plaques with some structures that resemble NFTs (+++).