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. 2022 Mar;192(3):484–502. doi: 10.1016/j.ajpath.2021.11.008

Figure 4.

Figure 4

Exogenous leptin increases mRNA expression of gene markers of fibrosis in multidrug resistance protein 2 knockout (Mdr2KO) mice. mRNA expression of a series of genes was assessed in livers of male and female Mdr2KO and FVB/NJ (FVBN) mice that had been treated with leptin or vehicle. Gene markers of fibrosis included desmin (A), α-smooth muscle actin (α-SMA; B), collagen type 1A1 (Col1A1; C), matrix metalloproteinase 2 (MMP2; D), tissue inhibitor of metalloproteinase 1 (TIMP1; E), and transforming growth factor (TGF)-β1 (F). N = 6 (A–F). ∗P < 0.05 for leptin versus vehicle; †P < 0.05 for Mdr2KO versus FVBN mice.