Supplemental Figure S2.

Cytochrome P450-2E1 CYP2E1) protein expression and enzyme activity in lipopolysaccharide (LPS) ± acetaminophen (APAP)–treated rats. Rats were administered phosphate-buffered saline (PBS) vehicle or 5 mg/kg LPS, followed by PBS vehicle or 200 mg/kg APAP 1 hour later. Liver protein lysates (A) or microsomes (B) were prepared for Western blot analysis and CYP2E1 enzyme activity determinations, respectively. The data shown are means of three separate determinations ± SD. n = 6 to 8 per group (A and B).