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. Author manuscript; available in PMC: 2022 Mar 4.
Published in final edited form as: J Cell Biochem. 2019 Apr 22;120(9):14688–14699. doi: 10.1002/jcb.28730

FIGURE 2.

FIGURE 2

SP1/KLF4 binding motif is enriched in the promoter regions and demethylated during odontoblastic differentiation. A, Genome-wide changes of DNA methylation during odontoblastic differentiation. B, UCSC genome browser showing the location of methylated peaks in the promoter of Klf4. C, UCSC genome browser showing the location of methylated peaks in the promoter of Wnt5a. D, Relative expression level for example genes whose promoters were affected by DNA methylation. E, Average diagram of DNA methylation peaks length before and after odontoblastic differentiation. F, Enriched de novo motif in D0-specific DNA methylation peaks. G, Enriched de novo motifs in D9-specific DNA methylation peaks. H, Comparison of top enriched motif in D0 with known SP1 and KLF4 motifs (weighted matrix)