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. 2021 Dec 18;16(5):1072–1090. doi: 10.1002/1878-0261.13151

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© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — RPPA profiling of breast cancer cell lines treated with AZD0424. (A), RPPA profiling of AZD0424‐treated breast cancer cell lines. (B) RPPA profiling of total and phosphorylated SRC (Tyr419) in breast cancer cells treated with AZD0424. Mean relative fluorescence intensity (RFI) is shown ± SD (n = 3 technical replicates). (C) Western blot analysis of cell lysates from breast cancer cell lines treated with AZD0424 probed with anti‐SRC and anti‐SRC pY419 antibodies. (D) Cluster of antibodies that display AZD0424 concentration‐dependent inhibition from (A).