Fig. 6.

SRC and MEK inhibitor combinations combine to block tumour cell invasion. (A), Organotypic invasion assay. Cells were cultured on top of fibroblast–collagen matrices and allowed to proliferate and invade over a 7‐day period with DMSO, AZD0424 (2000 nm), trametinib (5 nm) or a combination of the two. Images show typical fields of view from H&E‐stained sections from n = 3 independent experiments. (B) Quantification of organotypic invasion in (A). Data are normalised to DMSO values and displayed as means ± SEM (n = 3 independent experiments). *P < 0.05; **P < 0.01; ***P < 0.001 (one‐way ANOVA). Scale bar is 200 μm.