Comparison 2. Higher‐dose anticoagulants versus lower‐dose anticoagulants (long term).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 All‐cause mortality	1	590	Risk Ratio (IV, Random, 95% CI)	1.07 [0.89, 1.28]
2.2 Necessity for additional respiratory support	1	590	Risk Ratio (IV, Random, 95% CI)	Not estimable
2.3 Deep vein thrombosis	1	590	Risk Ratio (IV, Random, 95% CI)	1.39 [0.45, 4.33]
2.4 Pulmonary embolism	1	590	Risk Ratio (IV, Random, 95% CI)	0.40 [0.08, 2.03]
2.5 Major bleeding	1	590	Risk Ratio (IV, Random, 95% CI)	1.74 [0.51, 5.87]
2.6 Adverse events (minor bleeding)	1	590	Risk Ratio (IV, Random, 95% CI)	2.32 [0.90, 5.95]
2.7 Adverse events (stroke)	1	590	Risk Ratio (IV, Random, 95% CI)	0.99 [0.06, 15.80]
2.8 Adverse events (acute peripheral arterial thrombosis)	1	590	Risk Ratio (IV, Random, 95% CI)	Not estimable
2.9 Adverse events (myocardial infarction)	1	590	Risk Ratio (IV, Random, 95% CI)	Not estimable
2.10 Adverse events (atrial fibrillation)	1	590	Risk Ratio (IV, Random, 95% CI)	0.50 [0.13, 1.97]
2.11 Adverse events (thrombocytopenia)	1	590	Risk Ratio (IV, Random, 95% CI)	12.91 [0.73, 228.18]