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. 2022 Mar 4;2022(3):CD013739. doi: 10.1002/14651858.CD013739.pub2

Albani 2020.

Study characteristics
Methods
  • Study design: prospective cohort NRS

  • Type of publication: peer‐reviewed journal publication

  • Setting and dates: hospital, 20 February 2020‐10 March 2020

  • Country: Italy

  • Language: English

  • Number of centres: 1

  • Trial registration number: NR

Participants
  • Number of participants: 1403 allocated (experimental = 799; comparator = 604), 27 excluded (1 < 18 years, 26 were still admitted to the hospital and, because of this, the discharge status was not available at time of analysis), 1376 analysed (experimental = 780; comparator = 596)

  • Age, years (mean ± SD): 68.66 ± 12.62 (experimental), 70.6 ± 15.01 (comparator)

  • Gender (male/female): 545/254 (experimental), 379/225 (comparator)

  • Comorbidities (experimental/comparator): hypertension 35.9%/35.1%, diabetes 21.8%/19%

  • Confounding factors: prior anticoagulation (experimental = 53, comparator = 13), surgery (NR), cancer (NR), antiplatelet use (NR), history of VTE (NR)

  • Type of ventilator support: NR


Inclusion criteria
  • Admitted to the hospital

  • Real time‐PCR from a nasopharyngeal swab or bronchoalveolar lavage resulted positive for SARS‐CoV‐2


Exclusion criteria
  • Age < 18 years

  • Being still admitted to hospital so that a definitive outcome was not available at the time of analysis

Interventions
  • Experimental: anticoagulation with enoxaparin 40‐80 mg/day, duration 3‐9 days

  • Comparator: without anticoagulation

  • Concomitant therapy: NR

  • Duration of follow‐up: until death or hospital discharge

Outcomes Primary outcomes
  • Mortality


Secondary outcomes
  • Admission to ICU 

  • Hospital length of stay

  • PE

  • VTE

  • Acute myocardial infarction

  • Cerebral infarction

  • Haemorrhagic events

Notes
  • Sponsor/funding: quote "The authors received no specific funding for this work."

  • COIs: quote "The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

  • Protocol not available