WHO progression scale ≤ 5 (time frame: day 4) range from 0 (healthy) to 10 (death) values ≤ 5 correspond to the absence of any oxygen supply beside nasal or facial mask
WHO progression scale (time frame: day 4, 7 and 14) range from 0 (healthy) to 10 (death)
Overall survival (time frame: day 14, 28 and 90)
Length of hospital stay (time frame: day 28)
Length of ICU stay (time frame: day 28)
Time to oxygenation supply independency (time frame: day 28)
Time to ventilator (non‐invasive or invasive) (time frame: day 28)
Rate of AKI (time frame: day 28) according to AKI classification system
Time to renal replacement therapy initiation (time frame: day 28)
Rate of clinically overt PE or proximal DVT (time frame: day 14 and day 90) confirmed by objective testing
Rate of clinically overt arterial thrombosis (time frame: day 14 and day 90) confirmed by objective testing
Rate of unscheduled central venous catheter replacement for catheter dysfunction (time frame: day 28)
Rate of central venous catheter‐related DVT (time frame: day 28) as a thrombus extending from the catheter into the lumen of the deep vein where the catheter is inserted diagnosed with radiologic imaging in case of a clinical suspicion of upper/lower limb DVT or PE or compulsory catheter removal
Rate of unscheduled indwelling arterial catheter replacement for catheter dysfunction (time frame: day 28)
Rate of acute clotting leading to the replacement the renal replacement therapy circuit stratified by regional citrate anticoagulation or not (time frame: day 28)
Time to acute clot formation within the oxygenator (acute oxygenator thrombosis) leading to the exchange of an ECMO system (time frame: day 28)
Time to acute clot formation within the pump head (pump head thrombosis) leading to the exchange of an ECMO system (time frame: day 28)
Incidence of AEs (time frame: day 28)