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. 2022 Feb 17;13:806837. doi: 10.3389/fphar.2022.806837

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Copyright © 2022 He, Xu, Liu, Yang, Zhang, Li, Zhang, Wang, Zhang, Liu, Xu, Ding, Li, Gao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LA enhanced the short-term clonogenic capacity of HSPCs in vitro. (A) Colonies derived from LA-treated (10 µM) cells in serum-free 4-d system following an additional 14-d culture in H4434 methylcellulose (n = 3). All data represent the means ± SD. Compared with fresh unless specified. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 and ns = not significant by two-tailed unpaired Students’ t-test. (B) Representative morphological images of CFU colonies (BFU-E, CFU-E, CFU-GM, CFU-GEMM). Scale bar, 200 µm.