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. 2022 Mar 4;3(3):100557. doi: 10.1016/j.xcrm.2022.100557

Figure 5.

Figure 5

Enriched immunoglobulin gene expression and antibody response to incident SARS-CoV-2 infection

(A and B) (A) Frequency of B cell (N, naive; CM, classical memory; AM, activated memory; PC, plasma cells; PB, plasmablasts) subsets among total CD19-positive cells and (B) Ki67-positive CD19 cells in PBMCs from six NICs and seven individuals with co-incident infection, showing individual data points and the median (bars).

(C) Heatmap of immunoglobulin constant heavy- and light-chain gene expression in blood per individual (columns) stratified by time to first positive SARS-CoV-2 infection, compared with NIC and convalescent (Conv) samples 5–6 months after incident infection, presented as standardized (Z) scores of transcripts per million (TPM) using mean and SD of NIC.

(D and E) Blood TPM of (D) IGHG1 and (E) relative IgG anti-S1 antibody levels stratified by time to first positive SARS-CoV-2 infection, compared with NIC and Conv samples. Individual data points shown with violin plots depicting median, IQR, and frequency distributions (∗FDR < 0.05 by Kruskal-Wallis test for each group compared with NIC).