Table 1.
Study design | Follow-up (months) | Population | MES 0 or 1 | Clinical relapse | Δ% relapse | |
---|---|---|---|---|---|---|
Barreiro-de Acosta et al. [32] (Spain) | Prospective | 12 | 187 |
187 Mayo 0 = 126 (67.3%) Mayo 1 = 61 (32.7%) |
49 (26.2%) Mayo 0 = 24 (19.3%) Mayo 1 = 25 (41%) |
Δ% = 21.7; p < 0.01 |
Narang et al. [40] (India) | Prospective | 12 | 76 |
46 Mayo 0 = 36 (78.3%) Mayo 1 = 10 (21.7%) |
12 (26.1%) Mayo 0 = 6 (16.7%) Mayo 1 = 6 (60%) |
Δ% = 43.3 |
Ponte et al. [30] (Portugal) | Retrospective | 46–72 | 82 |
60 Mayo 0 = 32 (53.3%) Mayo 1 = 28 (46.7%) |
19 (31.7%) Mayo 0 = 6 (18.8%) Mayo 1 = 13 (46.4%) |
Δ% = 27.6; p = 0.02 |
Boal Carvalho et al. [34] (Portugal) | Retrospective | 12 | 138 |
138 Mayo 0 = 61 (44.2%) Mayo 1 = 77 (55.8%) |
28 (20.3%) Mayo 0 = 7 (11.5%) Mayo 1 = 21 (27.3%) |
Δ% = 15.8; p = 0.022 |
Yokoyama et al. [35] (Japan) | Retrospective | 60 | 38 |
24 Mayo 0 = 9 (37.5%) Mayo 1 = 15 (62.5%) |
11 (45.8%) Mayo 0 = 2 (22%) Mayo 1 = 9 (60%) |
Δ% = 38 |
Kim et al. [31] (South Korea) | Retrospective | 80 | 215 |
200 Mayo 0 = 113 (56.5%) Mayo 1 = 87 (43.5%) |
51 (25.5%) Mayo 0 = 22 (19.5%) Mayo 1 = 29 (33.3%) |
Δ% = 13.8; p < 0.023 |
Yoshino et al. [36] (Japan) | Retrospective | 16 | 298 |
88 Mayo 0 = 43 (48.9%) Mayo 1 = 45 (51.1%) |
21 (23.9%) Mayo 0 = 7 (33.3%) Mayo 1 = 14 (66.7%) |
Δ% = 33.4; p = 0.167 |
López-Palacios et al. [37] (Spain) | Prospective | 27 | 20 |
13 Mayo 0 = 10 (76.9%) Mayo 1 = 3 (23.1%) |
2 (15.4%) Mayo 0 = 1 (10%) Mayo 1 = 1 (33.3%) |
Δ% = 23.3 |
Yamamoto et al. [27] (Japan) | Prospective | 12 | 164 |
164 Mayo 0 = 84 (51%) Mayo 1 = 80 (49%) |
46 (28%) Mayo 0 = 19 (22.6%) Mayo 1 = 27 (33.8%) |
Δ% = 11.2; p = 0.16 |
Frieri et al. [33] (Italy) | Prospective | 36 | 52 |
46 Mayo 0 = 29 (63%) Mayo 1 = 17 (37%) |
20 (43.5%) Mayo 0 = 9 (31%) Mayo 1 = 11 (64.7%) |
Δ% = 33.7; p < 0.0001 |
Lobatón et al. [28] (Belgium, Spain) | Prospective | 12 | 96 |
96 Mayo 0 = 63 (66%) Mayo 1 = 33 (34%) |
22 (23%) Mayo 0 = 13 (21%) Mayo 1 = 9 (27%) |
Δ% = 6; p = 0.438 |
Osterman et al. [29] (USA) | Prospective | 12 | 100 |
61 Mayo 0 = 5 (8.2%) Mayo 1 = 56 (91.8%) |
8 (13.1%) Mayo 0 = 0 (0%) Mayo 1 = 8 (14.3%) |
Δ% = 14.3 |
Inoue et al. [41] (Japan) | Retrospective (Abstract) | 39 | 331 |
254 Mayo 0 = 176 (69%) Mayo 1 = 78 (31%) |
53 Mayo 0 = 20 (11.4%) Mayo 1 = 33 (42.3%) |
Δ% = 30.9; p = 0.017 |
Kanazawa et al. [39] (Japan) | Retrospective | 24 | 166 |
166 Mayo 0 = 91 (54.8%) Mayo 1 = 75 (45.2%) |
9 Mayo 0 = 3 (3.3%) Mayo 1 = 6 (8%) |
Δ% = 4.7 |
Sakemi et al. [38] (Japan) | Retrospective (Abstract) | 36 | 74 |
74 Mayo 0 = 23 (31%) Mayo 1 = 51 (69%) |
26 Mayo 0 = 2 (9%) Mayo 1 = 23 (46%) |
Δ% = 37 |