Fig. 9.

Hsa_circ_0000277 targeted miR-873-5p/SOX4 to facilitate tumorigenesis and DDP resistance in vivo. A Tumor volume was measured in each group every 7 days after PBS/DDP injection. B After 28 days, mice were sacrificed and tumor weight was determined. C, D RT-qPCR was used for the level detection of hsa_circ_0000277 (C) and miR-873-5p (D). E SOX4 protein level was assayed in each group using western blot. F SOX4, β-catenin, c-myc, and cyclin D1 protein levels in tissues were examined by IHC assay. G Schematic illustration of the hsa_circ_0000277/miR-873-5p/SOX4 axis in tumor growth and chemoresistance of ESCC in vivo. *P < 0.05