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. 2022 Mar 4;20:108. doi: 10.1186/s12967-022-03309-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The non-linear dose–response relationship between bilirubin and hypertension. Restricted cubic spine with 4 knots was performed to determine the bilirubin (STB, UCB, and CB)-hypertension dose–response relationship. The solid blue line represents the dose–response curve with multivariable Cox model, and the pink shading indicates the 95% confidence interval. STB, UCB, and CB exhibited bidirectional effects to hypertensive risk with the threshold concentration of 12.17 μmol/L, 8.59 μmol/L, and 3.47 μmol/L, respectively