Table 4.
Prospective analysis of associations between STB levels and hypertension incidence
| STB quartiles | |||||
|---|---|---|---|---|---|
| 1 < 9.3 μmol/L |
2 9.3 ~ 11.8 μmol/L |
3 11.9 ~ 15.2 μmol/L |
4 > 15.3 μmol/L |
P for trend | |
| Crude Model | Reference | 1.14 (0.85–1.52) | 1.40 (1.05–1.85) | 1.49 (1.13–1.97) | 0.017 |
| Model 1 | Reference | 1.10 (0.82–1.47) | 1.49 (1.12–1.97) | 1.68 (1.27–2.22) | < 0.001 |
| Model 2 | Reference | 1.11 (0.83–1.48) | 1.50 (1.13–1.99) | 1.68 (1.27–2.23) | < 0.001 |
| Model 3 | Reference | 1.21 (0.90–1.63) | 1.60 (1.20–2.12) | 1.76 (1.32–2.34) | < 0.001 |
| Model 4 | Reference | 1.19 (0.89–1.60) | 1.46 (1.10–1.94) | 1.68 (1.26–2.23) | 0.002 |
Multivariable-adjusted Cox regression models were used to assess the hypertension incidence risk by STB quartiles. Crude model: Only included STB level at the baseline. Multivariable model 1: Included variables of age, gender, BMI, and WC on the basis of the Crude model. Multivariable model 2: Further included variables of SBP, DBP, and DM at baseline on the basis of the Multivariable model 1. Multivariable model 3: Further included variables of FPGlog10, AST, and SCrSQRT on the basis of the Multivariable model 2. Multivariable model 4: Further included the variable of smoking status on the basis of the Multivariable model 3
STB, serum total bilirubin; BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; T2DM, type 2 diabetes mellitus; AST, aspartate aminotransferase; FPG, fasting plasma glucose; SCr, serum creatinine