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. 2021 Dec 20;2(1):ltab025. doi: 10.1093/immadv/ltab025

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© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Immunology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Cleavage of LAG-3 from the cell membrane. Soluble LAG-3 is produced when membrane-bound LAG-3 is cleaved by matrix metalloproteinases ADAM10 or ADAM17 between the D4 and transmembrane domains. The role of sLAG-3 is still unknown.