Table 7.
All-grade non-hematologic laboratory abnormalities occurring in >20% of patients on OPTIC.
| Laboratory test | Cohort A 45 mg → 15 mg (n = 94) |
Cohort B 30 mg → 15 mg (n = 94) |
Cohort C 15 mg (n = 94) |
Total (N = 282) |
|---|---|---|---|---|
| Liver Function Tests | ||||
| ALT increased | 46 (49%) | 29 (31%) | 37 (39%) | 112 (40%) |
| AST increased | 38 (40%) | 22 (23%) | 26 (28%) | 86 (31%) |
| Alkaline phosphatase increased | 22 (23%) | 18 (19%) | 20 (21%) | 60 (21%) |
| Pancreatic Enzymes | ||||
| Lipase increased | 32 (34%) | 26 (28%) | 22 (23%) | 80 (28%) |
| Other Chemistry | ||||
| Glucose increased | 43 (46%) | 35 (37%) | 37 (39%) | 115 (41%) |
| Triglycerides increased | 39 (42%) | 29 (31%) | 27 (29%) | 95 (36%) |
| BNP | 36 (38%) | 29 (31%) | 22 (23%) | 87 (31%) |
| Cholesterol | 33 (35%) | 17 (18%) | 22 (23%) | 72 (26%) |
| Phosphate decreased | 25 (27%) | 27 (29%) | 21 (22%) | 73 (26%) |
| Bicarbonate decreased | 25 (27%) | 19 (20%) | 24 (26%) | 68 (24%) |
Abbreviations: ALT, alanine transferase; AST, aspartate aminotransferase; BNP, B-type natriuretic peptide.