Table 3.

Effects of FG/FI/T2D genetic risk scores on obesity

Model	Obese (N = 205) versus non-obese (N = 1350) (control group 1) a				Obese (N = 205) versus non-overweight (N = 639) (control group 2) b
	Unadjusted		Adjusted c		Unadjusted		Adjusted c
	OR (95% CI) c	P-value	OR (95% CI) c	P-value	OR (95% CI) c	P-value	OR (95% CI) c	P-value
Weighted GRS
GRS_FG	1.00 (0.86–1.15)	0.96	0.97 (0.83–1.13)	0.74	1.00 (0.86–1.18)	0.96	1.00 (0.84–1.19)	0.99
GRS_FI	0.98 (0.85–1.13)	0.78	0.98 (0.84–1.13)	0.74	0.94 (0.81–1.10)	0.48	0.93 (0.79–1.10)	0.41
GRS_T2D	0.93 (0.80–1.07)	0.31	0.91 (0.78–1.06)	0.22	0.99 (0.85–1.15)	0.89	0.99 (0.84–1.17)	0.91
Unweighted GRS
GRS_FG	0.95 (0.82–1.10)	0.48	0.93 (0.80–1.09)	0.36	0.94 (0.30–1.03)	0.45	0.93 (0.79–1.11)	0.44
GRS_FI	0.99 (0.86–1.15)	0.93	0.99 (0.85–1.15)	0.86	0.96 (0.82–1.11)	0.60	0.95 (0.80–1.12)	0.52
GRS_T2D	0.97 (0.84–1.12)	0.68	0.96 (0.82–1.12)	0.58	1.02 (0.88–1.20)	0.77	1.02 (0.86–1.20)	0.83

FG, fasting glucose; FI, fasting insulin; GRS, genetic risk score; SDS, standard deviation score; T2D, type 2 diabetes.

^aObese individuals: BMI SDS > =2; non-obese individuals: −2 < BMI SDS < 2.

^bObese individuals: BMI SDS > =2; non-overweight individuals: −1 < BMI SDS < 1.

^cAdjusted for age, sex and family history of T1D and T2D.